Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 16;17(1):323–331. doi: 10.3892/ol.2018.9584

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 4. — HBV-associated exosomes modulate drug resistance via CMA pathway activation. (A) Western blotting revealed that Lamp2a was highly expressed following treatment with oxaliplatin in the HBV-associated exosome group compared with in the non-HBV exosome and blank control groups, and (B) that Lamp2a was upregulated by HBV-associated exosomes in a concentration-dependent manner. (C) Transfection efficiency of shRNA as assessed using fluorescence microscopy. (D) Interference efficiency of shRNA in HepG2 cells as assessed by western blotting. (E) The anti-apoptotic effects of HBV-associated exosomes in HepG2 cells were reversed by Lamp2a silencing. Lamp2a, lysosome-associated membrane protein; HBV, hepatitis B virus; oxa, oxaliplatin; CMA, chaperone-mediated autophagy; shRNA, short hairpin RNA; UR, upper right; LR, lower right; Ctr, control; PBS, phosphate-buffered saline; NC, negative control; GAPDH, glyceraldehyde 3-phosphate dehydrogenase.