Table 2.

Relevant Criteria for Top-Down and Bottom-Up Reimbursement Pathways.

Criterion	Top-down reimbursement pathway	Bottom-up reimbursement pathway
Coverage	● National/large population	● Local/regional/payer-specific population
Evidence	● Usually randomized controlled trials (RCTs)	● Any type, particularly real-world data (RWD)
Timeframe	● Long	● Moderate