Table 4.

The effects of a 6-week administration of 13-cis-RA (1 mg/kg/day, i.p.) and a 1-week administration of BLEB (125 nmol/day, intra-arterial) on basal pressure (BP, cm H₂O), voided volume (VV, ml), post-void residual (PVR, ml), intercontraction interval (ICI, s), bladder compliance (BC, ml/cm H₂O), detrusor overactivity index (DOI, cm H₂O/ml), nonvoiding contractions frequency (FNVC, times/filling phase), and volume threshold to elicit NVC (VTNVC, %)

Treatment	BP, cm H2O	VV, ml	PVR, ml	ICI, s	BC, ml/cm H2O	DOI, cm H2O/ml	FNVC, times/filling phase	VTNVC, %
Control	2.37 ± 0.13	0.82 ± 0.03	0.05 ± 0.004	943.8 ± 26.52	0.21 ± 0.006	66.60 ± 6.75	0.41 ± 0.05	85.47 ± 4.72
13-cis-RA	3.48 ± 0.26**	0.61 ± 0.04**	0.06 ± 0.004	813.9 ± 28.65*	0.18 ± 0.006	143.0 ± 13.79***	2.34 ± 0.28***	58.12 ± 5.00***
BLEB	2.53 ± 0.24	0.71 ± 0.06	0.06 ± 0.004	891.3 ± 43.14	0.17 ± 0.008*	64.07 ± 5.81	0.99 ± 0.22	63.35 ± 4.32**
13-cis-RA + BLEB	2.58 ± 0.23#	0.80 ± 0.05#	0.07 ± 0.006	1022.0 ± 52.33###	0.22 ± 0.012##	74.07 ± 5.99###	1.39 ± 0.20##	93.26 ± 5.67###

*p < 0.05, **p < 0.01, ***p < 0.001 vs control, #p < 0.05, ##p < 0.01, ###p < 0.001 vs. 13-cis-RA, by the two-way analysis of variance (two-way ANOVA) followed by a Bonferroni post hoc test, n = 15 in each group. BP: 13-cis-RA effect [F(1,56) = 6.413, p = 0.0142], BLEB effect [F(1,56) = 2.655, p = 0.1088), 13-cis-RA × BLEB interaction [F(1,56) = 5.417, p = 0.0236)]. VV: 13-cis-RA effect [F(1,56) = 1.410, p = 0.2401], BLEB effect [F(1,56) = 2.655, p = 0.3603), 13-cis-RA × BLEB interaction [F(1,56) = 0.8508, p = 0.0042)]. PVR: 13-cis-RA effect [F(1,56) = 1.759, p = 0.1902], BLEB effect [F(1,56) = 5.545, p = 0.0221), 13-cis-RA × BLEB interaction [F(1,56) = 0.5690, p = 0.4538)]. ICI: 13-cis-RA effect [F(1,56) = 1.759, p = 0.1902], BLEB effect [F(1,56) = 5.545, p = 0.0221), 13-cis-RA × BLEB interaction [F(1,56) = 0.5690, p = 0.4538)]. BC: 13-cis-RA effect [F(1,56) = 1.657, p = 0.2033], BLEB effect [F(1,56) = 0.09135, p = 0.7636), 13-cis-RA × BLEB interaction [F(1,56) = 17.62, p < 0.0001)]. DOI: 13-cis-RA effect [F(1,56) = 24.43, p < 0.0001], BLEB effect [F(1,56) = 16.71, p = 0.0001), 13-cis-RA × BLEB interaction [F(1,56) = 0.5690, p = 0.0004)]. FNVC: 13-cis-RA effect [F(1,56) = 30.00, p < 0.0001], BLEB effect [F(1,56) = 0.7746, p = 0.3826), 13-cis-RA × BLEB interaction [F(1,56) = 12.96, p = 0.0007)]. VTNVC: 13-cis-RA effect [F(1,56) = 0.06678, p = 0.7970], BLEB effect [F(1,56) = 1.727, p = 0.1941), 13-cis-RA × BLEB interaction [F(1,56) = 33.41, p < 0.0001)]