Table 1.
Comparative efficacy of anti-diabetic agents for the treatment of NAFLD.
| Medications | Insulin Resistance | Body Weight | Body Fat | AST/ALT | Liver Histology |
|---|---|---|---|---|---|
| Biguanides (Metformin) [11,12,13,14,15,16] | Decreased | Decreased | Decreased | Inconclusive | Inconclusive |
| Thiazolidinediones [17,18,19,20,21] | Decreased | Increased | Increased | Decreased | Decreased |
| GLP-1r agonists [22,23,24,25,26,27] | Decreased | Decreased | Decreased | Decreased | Decreased |
| DPP-4 inhibitors [28,29,30,31,32] | Decreased | No Effect | No Effect | Decreased/No Effect | No Effect |
| SGLT2 inhibitors [33,34,35] | Decreased | Decreased | Decreased | Decreased | Inconclusive |