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Schematic of exons 45–55 skipping using cocktail antisense oligonucleotides (AOs) for DMD exons 48–50 deletion. Individual AOs are designed to skip each exon within the region from exon 45 to 55. Native out-of-frame mRNAs cannot be translated into dystrophin due to a newly generated premature stop codon in exon 51. Skipping the entire exons 45–55 region by treatment of an AO cocktail leads to the production of truncated but functional dystrophin.
