Figure 7.

Theoretical applicability of exons 3–9 skipping to patients with out-of- and in-frame deletions. From the Leiden DMD database, 3232 patients with out-of-frame deletions and 1611 with in-frame deletions were extracted and were calculated for the applicability of certain exon skipping strategies to out-of- (red) and in-frame deletions (blue), respectively. Exons 3–9 skipping might become a potential therapy for patients with deletions in the proximal hot spot region that cause more variable severity.