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. 2018 Nov 28;15(12):2686. doi: 10.3390/ijerph15122686

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Metabolomic data for pyrimidine metabolism in mouse liver after low-dose OP treatment. (A) The relative level of cytidine was increased significantly at the OP dosage of 1 μg/kg/day. (B) The relative level of uridine was increased significantly at the OP dosage of 1 μg/kg/day. (C) The mRNA level of Cda was increased significantly at the OP dosage of 1 μg/kg/day. (D) The protein level of Cda was increased significantly at the OP dosage of 1 μg/kg/day. (E) Schematic diagram showing that pyrimidine synthesis might be promoted in the livers of mice treated with low-dose OP. Significance level: * p < 0.05 compared with controls.