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(A) Main genetic abnormalities observed in TERTpWT-IDHWT glioblastomas. Data are reported in Diplas et al., 2018 [19]. (B) Recurrent somatic alterations reported in adult and pediatric glioblastomas. H3F3A mutations correspond to the cumulative frequency of three types of mutations: H3F3AG34R, H3F3AG34V, and H3F3AK27M. The HIST1H3B mutations correspond to the cumulative incidence of HIST1H3BK27M and HIST1H3CK27M. The data are reported in Sturm et al., 2017 [71].
