Table 1.
World Health Organization (WHO) histological classification of tumors of the central nervous system.
| Tumor Type | WHO Grade |
|---|---|
| Diffuse Astrocytic and oligodendroglial tumors | |
| Diffuse astrocytoma, IDH mutant | II |
| Anaplastic astrocytoma, IDH mutant | III |
| Glioblastoma, IDH wild-type | IV |
| Glioblastoma, IDH-mutant | IV |
| Diffuse midline glioma K27M mutant | IV |
| Oligodendroglioma | II |
| Anaplastic oligodendroglioma | III |
| Oligoastrocytoma | II–III |
| Other Astrocytic tumors | |
| Pilocytic astrocytoma | I |
| Subependymal giant cell astrocytoma | I |
| Pleomorphic xanthoastrocytoma | II |
| Anaplastic pleomorphic xanthoastrocytoma | III |
| Other Gliomas | |
| Chordoid glioma of third ventricle | II |
| Angiocentric glioma | I |
| Ependymal tumors | |
| Ependymoma | II |
| Ependymoma, RELA fusion-positive | II–III |
| Subpendymoma | I |
| Myxopapillary ependymoma | I |
| Anaplastic ependymoma | III |
| Neuronal and mixed neuronal-glial tumors | |
| Gangliocytoma | I |
| Gangliolioma | I |
| Anaplastic ganglioglioma | III |
| Dysembryoplastic neuroepithelial tumor | I |
| Embryonal tumors | |
| Medulloblastoma (all subtypes) | IV |
| Medulloepithelioma | IV |
| Embryonal tumor with multilayered rosettes, C19M altered | IV |
| CNS embryonal tumor | IV |
| Meningiomas | |
| Meningioma | I |
| Atypical meningioma | II |
| Aplastic meningioma | III |
| Tumors of cranial and paraspinal nerves | |
| Neurofibroma | I |
| Perineurinoma | I |
| Schwannoma | I |
| Malignant peripheral nerve sheath tumor | II,II,III |
K27M: lysine27methionine; RELA: REL-associated; C19M: cysteine19methionine; CNS: central nervous system.