Table 6.
DNA methylation-based grading system for meningioma. Data are reported in Sahm et al., 2018 [216].
| Mutation | Cytogenetics | Histology | Prognosis | |
|---|---|---|---|---|
| MC ben-1 | NF2 | 22q deletion | Fibroblastic Transitional Atypical |
Good |
| MC ben-2 | TRAF7, AKT1, KLF4, SMO | Balanced | Secretory Transitional Meningothelial |
Good |
| MC ben-3 | 22q deletion 5 gain |
Angiomatous Transitional Atypical |
Good | |
| MC int-A | NF2 | 22q deletion 1p deletion |
Fibroblastic Transitional Atypical |
Intermediate |
| MC int-B | NF2, TERT | 22q deletion 1p, CDKN2A deletion |
Atypical Anaplastic |
Intermediate |
| MC mal | NF2, TERT | 22q deletion 1p, 10, CDKN2A deletion |
Anaplastic | Poor |
MC: methylation class.