Table 1.

ATP-binding cassette (ABC) transporter variants with a level of evidence from 1A to 2B.

Level	Variant	Gene	Drug	Effect	PMID
1A	rs11971167	CFTR	Ivacaftor	Efficacy	23891399 [20]
2A	rs2032582	ABCB1	Simvastatin	Efficacy	16321621 [21], 19891551 [22]
2A	rs1045642	ABCB1	Methotrexate	Toxicity	25007187 [23]
2A	rs1045642	ABCB1	Nevirapine	Toxicity	20017669 [24], 16912956 [25], 16912957 [26]
2A	ABCB1*1, ABCB1*2	ABCB1	Atazanavir	Toxicity/PK	19710077 [27] 22394315 [28]
2A	rs2032582 rs1045642	ABCB1	Ondansetron	Efficacy	20707787 [29] 25012726 [30]
2A	rs1045642	ABCB1	Digoxin	Others	18334914 [31], 12189368 [32], 10716719 [33]
2B	rs1045642	ABCB1	Fentanyl, methadone, morphine, opioids, oxycodone, tramadol	Dosage/efficacy	[34,35,36,37,38,39,40,41,42,43,44]
2B	ABCB1*1, ABCB1*2	ABCB1	Sunitinib	Efficacy
2B	rs1751034	ABCC4	Tenofovir	Pk	17597712 [45], 18398970 [46]
2B	rs2231142	ABCG2	Allopurinol	Dosage/efficacy	25676789 [47], 26810134 [48], 29341237 [49]
2B	rs2231142	ABCG2	Rosuvastatin	Efficacy	20130569 [50], 20679960 [51], 16784736 [52], 19474787 [53], 23930675 [54], 23930675 [54], 23876492 [55], 25630984 [56], 20207952 [57], 28322941 [58]