Table 1.
MICs (µg/mL) of 15 antibiotics against Abiotrophia isolates.
| Strains | PEN | AMP | AMX | PIP | CFZ | CAZ | CRO | CEC | IPM | GEN | ERY | CIP | MIN | VAN | SXT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A. defectiva | |||||||||||||||
| ATCC49176T | 0.125 | 0.016 | 0.016 | 1 | 1 | 16 | 1 | 0.125 | 0.125 | 32 | 0.5 | 1 | 0.063 | 0.25 | 256/4864 |
| NVS-47 | 0.125 | 0.032 | 0.016 | 1 | 2 | 16 | 1 | 0.125 | 0.125 | 32 | 0.5 | 1 | 0.032 | 0.25 | 256/4864 |
| PE7 | 0.032 | 0.016 | 0.016 | 4 | 1 | 8 | 1 | 0.125 | 0.125 | 32 | 0.5 | 1 | 0.063 | 0.25 | 256/4864 |
| YTS2 | 0.063 | 0.016 | 0.063 | 1 | 4 | 8 | 0.5 | 0.5 | 0.125 | 32 | 0.5 | 1 | 0.063 | 0.25 | 256/4864 |
| C8-3 | 0.25 | 0.125 | 0.063 | 1 | 2 | 8 | 0.5 | 0.5 | 0.125 | 16 | 0.25 | 0.5 | 4 | 0.25 | 0.016/0.3 |
| C1-2 | 2 | 0.5 | 0.25 | 4 | 16 | 16 | 1 | 32 | 0.25 | 16 | 128 | 1 | 8 | 0.25 | 128/2432 |
| YK-3 | 0.25 | 0.125 | 0.125 | 2 | 16 | 16 | 1 | 1 | 0.25 | 64 | 4 | 1 | 16 | 0.25 | 128/2432 |
| range | 0.032 | 0.016 | 0.016 | 1 | 1 | 8 | 0.5 | 0.125 | 0.125 | 16 | 0.25 | 0.5 | 0.032 | 0.016/0.3 | |
| | | | | | | | | | | | | | | | | | | | | | | | | | | 0.25 | | | |
| 2 | 0.5 | 0.25 | 4 | 16 | 16 | 1 | 32 | 0.25 | 64 | 128 | 1 | 16 | 256/4864 |
Type strain and strains NVS-47 and PE7 were derived from blood cultures with endocarditis and the others were oral isolates from healthy volunteers. MIC: minimum inhibitory concentration, PEN: benzylpenicillin, AMP: ampicillin, AMX: amoxicillin, PIP: piperacillin, CFZ: cefazolin, CAZ: ceftazidime, CRO: ceftriaxone, CEC: cefaclor, IPM: imipenem, GEN: gentamicin, ERY: erythromycin, CIP: ciprofloxacin, MIN: minocycline, VAN: vancomycin, SXT: sulfamethoxazole-trimethoprim complex.