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Summary of the biological matrices studied in this review and the tobacco smoke biomarkers determined in each matrix. Tobacco specific biomarkers are indicated in bold. CO: carbon monoxide; NNN: N′-nitrosonornicotine; NNK: 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone; COHb: Carboxyhemoglobin; 3HC: trans-3’-hydroxycotinine; NNAL: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; PAH: polycyclic aromatic hydrocarbon; VOC: volatile organic compounds.
