Table 1.

List of top 25 differentially expressed proteins with increased expression in PDAC tumour tissues compared to adjacent-normal tissues as determined by quantitative label-free mass spectrometric analysis using repeated measures ANOVA for paired sample analysis.

Accession	Protein Name	Gene	Peptides	p-Value	Fold-Change
P18564	Integrin beta-6	ITGB6	2	8.80 × 10−3	8.69
P02751	Fibronectin	FN1	3	4.67 × 10−2	7.95
P07996	Thrombospondin-1	THBS1	5	2.56 × 10−2	7.65
Q15063	Periostin	POSTN	8	2.06 × 10−2	7.34
O14498	Immunoglobulin superfamily containing leucine-rich repeat protein	ISLR	2	4.27 × 10−2	7.10
P31947	14-3-3 protein sigma	SFN	3	1.19 × 10−3	6.06
P35442	Thrombospondin-2	THBS2	5	1.33 × 10−2	6.02
O43294	Transforming growth factor beta-1-induced transcript 1 protein	TGFB1I1	2	5.98 × 10−3	5.75
Q8IU×7	Adipocyte enhancer-binding protein 1	AEBP1	3	1.72 × 10−2	5.59
P08174	Complement decay-accelerating factor	CD55	2	8.43 × 10−4	5.58
Q03518	Antigen peptide transporter 1	TAP1	2	4.62 × 10−3	5.00
Q03519	Antigen peptide transporter 2	TAP2	2	2.42 × 10−2	4.24
O15533	Tapasin	TAPBP	2	1.14 × 10−2	4.07
P23142	Fibulin-1	FBLN1	6	1.44 × 10−2	3.81
Q08380	Galectin-3-binding protein	LGALS3BP	3	7.24 × 10−3	3.80
P50454	Serpin H1	SERPINH1	2	5.73 × 10−4	3.64
P02792	Ferritin light chain	FTL	3	3.77 × 10−2	3.56
P98095	Fibulin-2	FBLN2	2	1.10 × 10−2	3.41
P20592	Interferon-induced GTP-binding protein Mx2	MX2	2	2.43 × 10−4	3.38
Q6UX06	Olfactomedin-4	OLFM4	3	4.26 × 10−2	3.27
Q01518	Adenylyl cyclase-associated protein 1	CAP1	2	3.22 × 10−2	3.22
Q01995	Transgelin	TAGLN	6	2.51 × 10−2	3.20
Q96HE7	ERO1-like protein alpha	ERO1A	11	2.39 × 10−3	3.16
Q92597	Protein NDRG1	NDRG1	2	3.28 × 10−2	3.15
Q6PIU2	Neutral cholesterol ester hydrolase 1	NCEH1	4	1.51 × 10−5	3.13