Figure 2.

Exosome biogenesis begins with budding into early endosome and further matures into late endosome, collectively known as multivesicular bodies (MVBs). Thus, formed multivesicular bodies fuse with plasma membrane to release exosomes into outer cellular environment to communicate with other cells. The late endosomes fuse with the lysosome to undergo degradation pathway. In recipient cells, exosomes are taken up by receptor-mediated endocytosis process and release their cargo contents.