Table 3.

Gene Ontology analysis of significantly regulated molecular functions in each treatment group. Date representing the top 12 significantly regulated molecular functions from each treatment group sorted from smallest to largest FDR-corrected p value. Only proteins significantly upregulated relative to saline were included in these analyses. Bolded GO terms are those that were significantly regulated in all three treatment groups.

	GO Molecular Function Complete	REFLIST (22262)	Upload Match	Upload Expected	Upload +/−	Fold Enrichment	Raw p-Value	FDR
G-CSF vs. Saline	binding (GO:0005488)	13001	296	200.9	+	1.47	2.49 × 10−28	1.13 × 10−24
	RNA binding (GO:0003723)	1019	73	15.75	+	4.64	2.86 × 10−27	6.48 × 10−24
	protein binding (GO:0005515)	8900	227	137.53	+	1.65	6.02 × 10−22	9.09 × 10−19
	heterocyclic compound binding (GO:1901363)	4917	152	75.98	+	2	1.82 × 10−19	2.07 × 10−16
	organic cyclic compound binding (GO:0097159)	5006	152	77.35	+	1.96	1.08 × 10−18	9.77 × 10−16
	mRNA binding (GO:0003729)	243	28	3.75	+	7.46	1.56 × 10−15	1.18 × 10−12
	protein-containing complex binding (GO:0044877)	1163	58	17.97	+	3.23	9.27 × 10−15	6.01 × 10−12
	enzyme binding (GO:0019899)	2260	84	34.92	+	2.41	7.23 × 10−14	4.10 × 10−11
	signaling receptor activity (GO:0038023)	2271	2	35.09	−	0.06	1.56 × 10−13	7.87 × 10−11
	structural molecule activity (GO:0005198)	613	39	9.47	+	4.12	3.37 × 10−13	1.53 × 10−10
	molecular transducer activity (GO:0060089)	2324	3	35.91	−	0.08	1.18 × 10−12	4.88 × 10−10
	transmembrane signaling receptor activity (GO:0004888)	2082	2	32.17	−	0.06	3.02 × 10−12	1.14 × 10−9
Coc. vs. Saline	protein binding (GO:0005515)	8900	170	96.35	+	1.76	2.40 × 10−21	1.09 × 10−17
	binding (GO:0005488)	13001	206	140.74	+	1.46	2.12 × 10−19	4.82 × 10−16
	structural molecule activity (GO:0005198)	613	32	6.64	+	4.82	5.44 × 10−13	8.23 × 10−10
	RNA binding (GO:0003723)	1019	41	11.03	+	3.72	7.98 × 10−13	9.05 × 10−10
	organic cyclic compound binding (GO:0097159)	5006	100	54.19	+	1.85	6.20 × 10−13	5.62 × 10−8
	heterocyclic compound binding (GO:1901363)	4917	98	53.23	+	1.84	1.34 × 10−10	1.02 × 10−7
	molecular transducer activity (GO:0060089)	2324	1	25.16	−	0.04	1.66 × 10−10	1.07 × 10−7
	identical protein binding (GO:0042802)	1840	52	19.92	+	2.61	1.98 × 10−10	1.12 × 10−7
	cytoskeletal protein binding (GO:0008092)	936	35	10.13	+	3.45	3.12 × 10−10	1.57 × 10−7
	signaling receptor activity (GO:0038023)	2271	1	24.58	−	0.04	4.19 × 10−10	1.90 × 10−7
	mRNA binding (GO:0003729)	243	18	2.63	+	6.84	4.91 × 10−10	2.02 × 10−7
	actin binding (GO:0003779)	411	22	4.45	+	4.94	1.85 × 10−9	7.00 × 10−7
G-CSF + Coc vs. Saline	binding (GO:0005488)	13001	167	108.62	+	1.54	7.88 × 10−21	3.57 × 10−17
	protein binding (GO:0005515)	8900	137	74.36	+	1.84	2.67 × 10−20	6.06 × 10−17
	identical protein binding (GO:0042802)	1840	46	15.37	+	2.99	1.67 × 10−11	2.52 × 10−8
	cytoskeletal protein binding (GO:0008092)	936	31	7.82	+	3.96	9.34 × 10−11	1.06 × 10−7
	RNA binding (GO:0003723)	1019	32	8.51	+	3.76	1.65 × 10−10	1.50 × 10−7
	structural molecule activity (GO:0005198)	613	24	5.12	+	4.69	6.58 × 10−10	4.97 × 10−7
	actin binding (GO:0003779)	411	19	3.43	+	5.53	3.48 × 10−9	2.25 × 10−6
	molecular transducer activity (GO:0060089)	2324	1	19.42	−	0.05	7.39 × 10−8	3.72 × 10−5
	heterocyclic compound binding (GO:1901363)	4917	74	41.08	+	1.8	6.61 × 10−8	3.75 × 10−5
	signaling receptor activity (GO:0038023)	2271	1	18.97	−	0.05	1.12 × 10−7	5.07 × 10−5
	organic cyclic compound binding (GO:0097159)	5006	74	41.83	+	1.77	1.38 × 10−7	5.68 × 10−5
	enzyme binding (GO:0019899)	2260	43	18.88	+	2.28	2.95 × 10−7	1.11 × 10−4