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. 2018 Oct 12;6(4):41. doi: 10.3390/proteomes6040041

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inhibition of GRK2 attenuates yohimbine-induced increases in ethanol-motivated behavior. (A) Experimental timeline. (B) CORT exposure consistently, but not significantly, tended to increase reinforcers earned and intake (inset) during ethanol self-administration. (C) Intra-basolateral amygdala inhibition of GRK2 blocks yohimbine-induced increases in breakpoint during progressive ratio testing, though the overall low number of reinforcers earned precluded the detection of differences in ethanol intake (inset). (D) GRK2 inhibition significantly reduced the reinstatement of ethanol seeking and tended to reduce the effects of yohimbine in increasing reinstatement. * p < 0.05 yohimbine (YOH) vs. vehicle (VEH); # p < 0.05 GRK2i vs. vehicle.