Table 2.
Spinophilin interacting proteins that had altered abundance following amphetamine treatment.
| Description | # PSMs | Normalized Abundance Ratio (Treatment)/(Control) | Normalized Abundance Ratio (log2): (Treatment)/(Control) |
|---|---|---|---|
| Decreased Interactions | |||
| E3 ubiquitin-protein ligase XIAP | 22 | 0.69 | −0.54 |
| Disks large homolog 3 | 143 | 0.67 | −0.58 |
| Granulins | 10 | 0.36 | −1.47 |
| Increased Interactions | |||
| Myelin proteolipid protein | 38 | 2.28 | 1.19 |
| Hemoglobin subunit alpha | 17 | 2.24 | 1.16 |
| ADP/ATP translocase 2 | 36 | 2.23 | 1.16 |
| Clathrin light chain A | 17 | 2.13 | 1.09 |
| Adenylyl cyclase-associated protein 2 | 8 | 2.10 | 1.07 |
| MCG10343, isoform CRA_b | 35 | 2.08 | 1.05 |
| Tubulin alpha-1B chain | 54 | 2.07 | 1.05 |
| Tubulin alpha chain (Fragment) | 54 | 2.03 | 1.02 |
| Cytochrome c oxidase subunit NDUFA4 | 13 | 2.03 | 1.02 |
| Profilin-2 | 14 | 2.02 | 1.02 |
| Reticulon (Fragment) | 20 | 2.02 | 1.01 |
| Myelin-oligodendrocyte glycoprotein | 18 | 2.01 | 1.01 |
| Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | 28 | 2.00 | 1.00 |
HA spinophilin was immunoprecipitated from saline and amphetamine-treated D1 Cre and A2A Cre mice. The abundance of the individual proteins was normalized to the abundance of spinophilin. A ratio of the abundance of proteins isolated from the amphetamine treated over the saline treated mice was generated. A subset of spinophilin interacting proteins that had at least eight spectral counts (PSMs) and had a decreased (<0.05) or increased (≥1.00) log2 ratio is shown. A complete list of interacting proteins (without contaminants) and their abundance ratios are shown in Table S2A.