Table 4.

Top 10 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with proteins that have amphetamine-dependent increases in spinophilin.

Term	Count	%	p Value	Bonferroni
mmu01200:Carbon metabolism	27	9.54	3.52 × 10−18	7.04 × 10−16
mmu05012:Parkinson’s disease	29	10.25	2.34 × 10−17	4.69 × 10−15
mmu05016:Huntington’s disease	32	11.31	9.23 × 10−17	2.22 × 10−14
mmu00190:Oxidative phosphorylation	26	9.19	4.42 × 10−15	8.88 × 10−13
mmu04721:Synaptic vesicle cycle	19	6.71	5.04 × 10−15	9.99 × 10−13
mmu00020:Citrate cycle (TCA cycle)	15	5.30	7.94 × 10−15	1.60 × 10−12
mmu05010:Alzheimer’s disease	27	9.54	1.82 × 10−13	3.65 × 10−11
mmu01130:Biosynthesis of antibiotics	29	10.25	3.85 × 10−13	7.70 × 10−11
mmu04961:Endocrine and other factor-regulated calcium reabsorption	15	5.30	1.92 × 10−11	3.84 × 10−9
mmu00010:Glycolysis/Gluconeogenesis	16	5.65	5.11 × 10−11	1.02 × 10−8

The 286 proteins that had an increased association with spinophilin (log2 ratio ≥ 0.5; Table S2A) were input into the DAVID Bioinformatics resource and analyzed using KEGG pathway analysis. The top 10 enriched pathways are shown. All pathways are given in Table S3.