Table 5.
Top 10 GO, BP, CC, and MF pathways associated with proteins that have amphetamine-dependent increases in spinophilin. The 286 proteins that had an increased association with spinophilin (log 2 ratio ≥ 0.05; Table S2A) were input into the DAVID Bioinformatics resource and analyzed using GO BP, CC, and MF pathway analyses. The top 10 enriched pathways are shown. All pathways are given in Table S4.
| Term | Count | % | PValue | Bonferroni |
|---|---|---|---|---|
| Biological Process | ||||
| GO:0006099~tricarboxylic acid cycle | 13 | 4.59 | 3.85 × 10−15 | 6.78 × 10−12 |
| GO:0006810~transport | 68 | 24.03 | 1.55 × 10−12 | 2.70 × 10−9 |
| GO:0006096~glycolytic process | 11 | 3.89 | 8.12 × 10−11 | 1.42 × 10−7 |
| GO:0006734~NADH metabolic process | 8 | 2.83 | 1.11 × 10−10 | 1.93 × 10−7 |
| GO:0046034~ATP metabolic process | 11 | 3.89 | 2.57 × 10−10 | 4.48 × 10−7 |
| GO:0015992~proton transport | 12 | 4.24 | 7.90 × 10−10 | 1.38 × 10−6 |
| GO:0015991~ATP hydrolysis coupled proton transport | 10 | 3.53 | 8.81 × 10−10 | 1.54 × 10−6 |
| GO:0050821~protein stabilization | 15 | 5.30 | 7.11 × 10−9 | 1.24 × 10−5 |
| GO:0015986~ATP synthesis coupled proton transport | 8 | 2.83 | 2.98 × 10−8 | 5.20 × 10−5 |
| GO:1904871~positive regulation of protein localization to Cajal body | 6 | 2.12 | 3.79 × 10−8 | 6.61 × 10−5 |
| Cellular Compartment | ||||
| GO:0043209~myelin sheath | 92 | 32.51 | 3.70 × 10−120 | 1.53 × 10−117 |
| GO:0070062~extracellular exosome | 159 | 56.18 | 2.16 × 10−65 | 8.91 × 10−63 |
| GO:0005739~mitochondrion | 88 | 31.10 | 3.66 × 10−27 | 1.51 × 10−24 |
| GO:0005829~cytosol | 88 | 31.10 | 4.60 × 10−26 | 1.90 × 10−23 |
| GO:0005737~cytoplasm | 173 | 61.13 | 3.24 × 10−22 | 1.34 × 10−19 |
| GO:0016020~membrane | 178 | 62.90 | 6.47 × 10−22 | 2.66 × 10−19 |
| GO:0014069~postsynaptic density | 32 | 11.31 | 5.02 × 10−21 | 2.07 × 10−18 |
| GO:0043005~neuron projection | 40 | 14.13 | 6.70 × 10−21 | 2.76 × 10−18 |
| GO:0043234~protein complex | 46 | 16.25 | 1.63 × 10−19 | 6.71 × 10−17 |
| GO:0005743~mitochondrial inner membrane | 37 | 13.07 | 2.23 × 10−19 | 9.20 × 10−17 |
| Molecular Function | ||||
| GO:0005515~protein binding | 138 | 48.8 | 1.12 × 10−22 | 6.18 × 10−20 |
| GO:0032403~protein complex binding | 36 | 12.7 | 2.54 × 10−18 | 1.40 × 10−15 |
| GO:0019901~protein kinase binding | 36 | 12.7 | 1.24 × 10−15 | 6.74 × 10−13 |
| GO:0044822~poly(A) RNA binding | 55 | 19.4 | 4.52 × 10−14 | 2.49 × 10−11 |
| GO:0000166~nucleotide binding | 74 | 26.1 | 2.72 × 10−13 | 1.50 × 10−10 |
| GO:0019904~protein domain specific binding | 27 | 9.5 | 5.67 × 10−13 | 3.13 × 10−10 |
| GO:0098641~cadherin binding involved in cell-cell adhesion | 26 | 9.2 | 1.77 × 10−12 | 9.79 × 10−10 |
| GO:0008022~protein C-terminus binding | 22 | 7.8 | 1.30 × 10−11 | 7.15 × 10−9 |
| GO:0005516~calmodulin binding | 19 | 6.7 | 5.09 × 10−10 | 2.81 × 10−7 |
| GO:0003779~actin binding | 25 | 8.8 | 6.35 × 10−10 | 3.51 × 10−7 |