Table 1.

Comparison of PCV10 and PCV13 antibody levels over time, with exact age at blood sampling as continuous variable and exchangeable correlation structure.

Serotype	Trend Over Time				Interaction
	PCV10		PCV13
	GMC Ratio per Month a	p-Value	GMC Ratio per Month a	p-Value	Direction b	p-Value
1	0.82	<0.001	0.82	<0.001	Negative	0.811
4	0.93	<0.001	0.81	<0.001	Negative	<0.001
5	0.79	<0.001	0.84	<0.001	Positive	0.019
6B	1.07	0.035	1.00	0.906	Negative	0.106
7F	0.86	<0.001	0.84	<0.001	Negative	0.252
9V	0.89	<0.001	0.78	<0.001	Negative	<0.001
14	0.81	<0.001	0.94	0.010	Positive	<0.001
18C	0.83	<0.001	0.76	<0.001	Negative	<0.001
19F	1.10	0.005	0.81	<0.001	Negative	<0.001
23F	0.99	0.824	0.83	<0.001	Negative	<0.001
3	0.98	0.519	0.72	<0.001	Negative	<0.001
6A	1.11	0.009	0.88	<0.001	Negative	<0.001
19A	1.08	0.015	0.79	<0.001	Negative	<0.001

^a Slope of the GMCs in time; ^b Positive interaction means: PCV13 response decreases less over time than PCV10; ^b Negative interaction means: PCV13 response decreases more over time than PCV10.