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Comparison of molecular markers of human adapted influenza strains.
| Gene Segment | Avian > Mammalian | Avian Isolates | Human Isolates | Activity |
|---|---|---|---|---|
| PB2 | K526R | 3.20% | 6.30% | increase polymerase activity, enhance virus replication |
| PB2 | A588V | 11.90% | 25% | higher polymerase activity, increased virulence mice |
| PB2 | E627K | 0.80% | 6.30% | associated with mammalian adaptation |
| PB2 | D701N | 0.05% | 6.30% | aerosol transmission guinea pigs |
