Table I.
Primary cancer.
| Case | Age, years | Histology | Site | Chemotherapy, cumulative doses | Radiation |
|---|---|---|---|---|---|
| 1 | 4 | Medulloblastoma | Cerebellar vermis | VCR, 0.6 mg/m2, CPM, 12,000 mg/m2 | Yes |
| CDDP, 360 mg/m2, VP16, 14,000 mg/m2 | 32 Gy (brain) | ||||
| TEPA, 800 mg/m2, LPAM, 280 mg/m2, | 18 Gy (spine) | ||||
| MTX (intrathecal injection), 72 mg/body | |||||
| 2 | 9 | Germ cell tumor | Anterior mediastinum | IFM, 18 g/m2, CBDCA, 4,500 mg/m2 | None |
| CDDP, 400 mg/m2, VP-16, 5,100 mg/m2 | |||||
| BLM, 45 mg/m2, PTX, 650 mg/m2 | |||||
| 3 | 1 | Anaplastic astrocytoma | Medulla oblongata | VCR, CPM, CDDP, VP-16, TEPA, L-PAM | Yes |
| (Cumulative doses are not applicable) | 40 Gy (brain) |
VCR, vincristine; CPM, cyclophosphamide; CDDP, cisplatin; VP16, etoposide; TEPA, thiotepa; LPAM, melphalan; MTX, methotrexate; IFM, ifosfamide; CBDCA, carboplatin; BLM, bleomycin; PTX, paclitaxel.