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. 2018 Sep 20;6(4):67. doi: 10.3390/vaccines6040067

Figure 8.

Figure 8

Catestatin (CST) reduces IL-8 and IL-18 release in LPS- and DSS-stimulated Caco-2 epithelial cell line through potentially the STAT3 pathway. Caco-2 cells were treated with 1× phosphate buffer saline (PBS) or CST (100 ng/mL) in medium for 24 h then challenged with LPS (1 μg/mL) or 5% DSS for an additional 24 h in the presence or absence of STAT3 inhibitor (10−5 M, STATTIC; Sigma, Mississauga, ON, Canada). (A,B) Protein and mRNA levels expression of IL-8 and IL-18 in LPS- and DSS-stimulated epithelial cells. One-way ANOVA was used to analyze the data followed by multiple comparison tests. Data represent mean ± SEM (n = 6–9). # Compared to control groups. Each experiment was repeated at least three times.