Table IV.
Toxicities by grade of severity, according to the CTCAE (version 4.03).
| Chemotherapy-related toxicity | Grade 1, n (%) | Grade 2, n (%) | Grade 3, n (%) | Grade 4, n (%) |
|---|---|---|---|---|
| Haematological | ||||
| Thrombocytopenia | 14 (38) | 5 (14) | 1 (3) | 1 (3) |
| Leukopenia | 11 (30) | 6 (16) | 1 (3) | 1 (3) |
| Neutropenia | 5 (14) | 4 (11) | 1 (3) | – |
| Lymphopenia | 3 (8) | 4 (11) | 3 (8) | 1 (3) |
| Anemia | 14 (38) | 3 (8) | – | – |
| Hypertransaminasemia | ||||
| ALT | 9 (24) | 1 (3) | – | – |
| AST | 1 (3) | – | – | – |
| γGT | 4 (11) | 2 (5) | – | – |
| Renal | ||||
| Creatinine increase | 7 (19) | – | 1 (3) | – |
| Gastrointestinal | ||||
| Nausea | 5 (14) | 2 (5) | – | – |
| Diarrhea | – | 1 (3) | 1 (3) | – |
| Mucositis | 1 (3) | – | 1 (3) | – |
| General | ||||
| Astenia | 6 (16) | 6 (16) | 1 (3) | – |
| Anorexia | – | 2 (5) | 6 (16) | – |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; γGT, γ-glutamyl transferase.