Table 2.

Gene ontology analysis of differentially expressed genes in patients with diabetic cardiomyopathy.

Expression	Category	Term	Count	%
Upregulated	GOTERM_BP_DIRECT	GO:0035589~G-protein-coupled purinergic nucleotide receptor signaling pathway	9	0.05
	GOTERM_BP_DIRECT	GO:0007155~fatty acid metabolism	8	0.05
	GOTERM_BP_DIRECT	GO:0001501~mitochondrial membrane potential	6	0.04
	GOTERM_BP_DIRECT	GO:0030198~extracellular matrix organization	6	0.04
	GOTERM_BP_DIRECT	GO:0007409~mitochondrial permeability transition	5	0.03
	GOTERM_CC_DIRECT	GO:0016021~integral component of membrane	42	0.25
	GOTERM_CC_DIRECT	GO:0005886~plasma membrane	37	0.22
	GOTERM_CC_DIRECT	GO:0070062~extracellular exosome	29	0.17
	GOTERM_CC_DIRECT	GO:0005615~extracellular space	22	0.13
	GOTERM_CC_DIRECT	GO:0005576~extracellular region	20	0.11
	GOTERM_MF_DIRECT	GO:0008270~glucose transporter	13	0.08
	GOTERM_MF_DIRECT	GO:0005509~calcium ion binding	11	0.07
	GOTERM_MF_DIRECT	GO:0008201~heparin binding	7	0.05
	GOTERM_MF_DIRECT	GO:0005518~collagen binding	5	0.03
	GOTERM_MF_DIRECT	GO:0050661~NADP binding	4	0.03
Downregulated	GOTERM_BP_DIRECT	GO:0006954~inflammatory response	11	0.07
	GOTERM_BP_DIRECT	GO:0008284~lipid intake	9	0.06
	GOTERM_BP_DIRECT	GO:0042493~response to drug	6	0.04
	GOTERM_BP_DIRECT	GO:0006955~immune response	6	0.04
	GOTERM_BP_DIRECT	GO:0002576~platelet degranulation	5	0.04
	GOTERM_CC_DIRECT	GO:0005886~plasma membrane	31	0.21
	GOTERM_CC_DIRECT	GO:0005615~extracellular space	23	0.15
	GOTERM_CC_DIRECT	GO:0005576~extracellular region	21	0.14
	GOTERM_CC_DIRECT	GO:0070062~extracellular exosome	21	0.14
	GOTERM_CC_DIRECT	GO:0005789~endoplasmic reticulum membrane	13	0.09
	GOTERM_MF_DIRECT	GO:0005515~protein binding	58	0.39
	GOTERM_MF_DIRECT	GO:0008083~mitochondrial uncoupling	5	0.03
	GOTERM_MF_DIRECT	GO:0005125~cytokine activity	5	0.03
	GOTERM_MF_DIRECT	GO:0003779~actin binding	5	0.03
	GOTERM_MF_DIRECT	GO:0016791~phosphatase activity	3	0.03

GO: gene ontology.