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. Author manuscript; available in PMC: 2019 Jan 2.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2018 Jul 21;138:1–8. doi: 10.1016/j.prostaglandins.2018.07.004

Fig. 6.

Fig. 6.

Effect of sEH ablation and HO-1 induction on EETs levels. The levels of isoforms of EETs (5, 6-EET, 8, 9-EET, 11, 12-EET, 14, 15-EET) and the total EETs (2.32 ± 0.22 mg vs. 0.61 ± 0.06 mg) levels were significantly (p < 0.05) increased in sEH KO mice compared to control mice. Since not all EETs are released as functional EETs, we decided to inject CoPP, a potent HO-1 inducer, to KO mice. As a result, we observed that administration of CoPP lead to a significant increase in all forms of EETs (5, 6-EET, 8, 9-EET, 11, 12-EET, 14, 15-EET) as well as total EETs levels compared to control mice and sEH KO without CoPP (Fig. 6A–F) (n = 4), * p < 0.05 vs.WT male, #p < 0.05 vs sEH (−/−) male.