Table 1.
Compound | Zbuffer | ZRNA | ZRNActrl | CVRNA | Hit | Notes |
---|---|---|---|---|---|---|
1 | 0.14 | 8.34 | 1.67 | 10.5 | Yes | Specific binder |
2 | 0.54 | 10.3 | 0.76 | 23.8 | No* | Specific binder ruled out by structure (e.g., polycation) |
3 | 0.99 | 10.0 | 7.37 | 10.1 | No | Nonspecific binder |
4 | 0.03 | 1.26 | 0.97 | 0.91 | Yes | False negative |
5 | 0.22 | 6.69 | −0.11 | 146 | Noa | False positive (e.g., dust particulate) |
6 | 13.0 | 3.03 | 4.15 | 3.8 | No | Autofluorescent compound |
These compounds mathematically satisfy the defined hit criteria, but were later ruled out upon visual inspection or based on structural features