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. 2019 Jan 2;12:1. doi: 10.1186/s13072-018-0245-6

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — BEC DNAm was consistently more variable than PBMC DNAm at the genome-wide and probewise level. a Distribution of reference range in C3ARE, GECKO and GECKOsub, showing significantly great variability in BEC versus PBMC (Wilcoxon p < 2.2 × 10⁻¹⁶ in each cohort). b Scatterplot of PBMC versus BEC reference range in each cohort. c Three examples of CpGs with the greatest reference range difference between tissues. Individuals from the GECKO cohort are shown in red and individuals from C3ARE are shown in blue