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. 2018 Nov 14;293(51):19546–19558. doi: 10.1074/jbc.RA118.003061

Figure 5.

Figure 5.

A modified mode of Bcl-XL recognition by p73-TAD. a, structure of the p73-TAD16 peptide bound to Bcl-XL. The p73-TAD16 peptide, shown in light green, is located at the center of the BH1, BH2, and BH3 domains, allowing it to interact with the residues from all three BH domains. b, the p73-TAD16 peptide is equally involved in the interaction with the Bcl-XL residues from the BH1, BH2, and BH3 domains. c, structures of Bcl-XL in complex with the pro-apoptotic BH3 peptides of Bak (PDB code 1BXL). The α1 helix, which is not involved in any peptide binding, is not shown for clarity. d, structure of Bcl-XL in complex with the pro-apoptotic BH3 peptides of Bad (PDB code 1G5J). e, structure of Bcl-XL in complex with the pro-apoptotic BH3 peptides of Bid (PDB code 4QVE). f, structure of Bcl-XL in complex with the pro-apoptotic BH3 peptides of PUMA (PDB code 2M04).