Figure 11.

Soluble Siglec-14 lacks bactericidal activity against NTHi. A, direct bactericidal activity assay in the presence or absence of soluble Siglec-14 (6 biological replicates). B, complement-mediated bactericidal activity assay in the presence or absence of soluble Siglec-14 (three biological replicates). Experiments were performed as described under “Experimental procedures.” No statistically significant difference (by Student's t test) in bacterial counts between soluble Siglec-14–supplemented and control groups was observed.