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. 2018 Oct 25;293(51):19909–19918. doi: 10.1074/jbc.RA118.005485

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© 2018 Mallette and Kimber.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 3. — Bioinformatics analysis of APK homologs. A, sequence similarity network of APK homologs. Sequences are connected by edges if E < e-50. Sequences are colored by phyla, as noted in the key. Phyla marked (c) are candidate phyla. APK homologs highlighted in B are indicated. B, gene organization of representative examples of APK homologs. Gene labels: BMC, bacterial microcompartment shell proteins; AT3, aminotransferase III; trans., transporter; 4HPH, 4-hydroxyphenylacetate 3-hydroxylase; FD, flavin reductase; HHMI, 5-carboxymethyl-2-hydroxymuconatedelta-isomerase; CHMD, 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase; DHPD, 3,4-dihydroxyphenylacetate 2,3-dioxygenase; FAAH, fumarylacetoacetate hydrolase; 2KPH, 2-keto-4-pentenoate hydratase; OHDH, 2-oxo-hept-3-ene-1,7-dioate hydratase; CTTD, catechol 2,3-dioxygenase.