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. 2019 Jan;29(1):18–28. doi: 10.1101/gr.238527.118

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© 2019 Amat et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Pol II read-through coincides with local contact map changes. (A) The Pol II ChIP-seq signal and the insulation score around PRLR and TRPS1 loci in nonstressed and NaCl-treated cells. (B) Hi-C contact maps of the PRLR and TRPS1 loci under both conditions (10-kb resolution). (C) Profiles of Pol II occupation of consensus TAD borders in nonstressed and NaCl-treated cells. The TAD borders were defined under nonstress conditions (allowing a 50-kb shift between replicates). Binding profiles were clustered using k-means and signals of 500 kb upstream of or downstream from each TAD border. Genomic loci and clustering are independent of Figure 3C.