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Combinatorial biosynthesis pathway of Ivermectins in S. avermitilis DQ03. Each polyketide skeleton was assembled by one equal 2-methylbutyryl-CoA (or isobutyryl-CoA) as starter units and 7 equal malonyl-CoA and 5 equal methylmalonyl-CoA as extending units. AT, acyltransferase; ACP, acyl carrier protein; KS, beta-ketoacyl synthase; DH, dehydratase; ER, enoylreductase; KR, ketoreductase; TE, thioesterase. The IveA1 DH-ER-KR domain set from Meilingmycin PKS module 2 was shown in magenta.
