Table 1.

Bacterial strains and plasmids used in this study.

Strain or plasmid	Relevant phenotype and/or characteristics	Source or Reference
pWDZ255	pUC18- meiDH2-ER2-KR2 + addA	This work
pWDZ256	pUC18-meiKR2+aveACP + addA	This work
14F9S	BAC recombinant, which harbors an ave cluster	[19]
pIJ778	A plasmid harboring Spectinomycin resistant gene aadA	[15]
pWHU2009	A plasmid harboring an ive cluster	This work
pWHU2010	A plasmid harboring an ive cluster without aveD	This work
pWDZ307	A plasmid for knockout of ave gene cluster in S. avermitilis 3-115	This work
S. nanchangensis NS3226	Wild-type strain, Meilingmycins producer	[12,13]
S. avermitilis 3-115	Avermectins producer	[20]
S. lividans 1326	Host for heterologous expression	CGMCC