TABLE 3.

Proteins correlated with plasma triglyceride concentrations in children of rural Nepal aged 6–8 years (n = 472)

Protein Name	na	r	R2	P	q	Percent Changeb	Accessionc	Referenced
apoC-II	472	0.54	0.29	4.20 × 10−20	7.22 × 10−17	47.2	32130518	(5, 53)
apoC-III	472	0.53	0.29	3.31 × 10−19	2.84 × 10−16	48.8	4557323	(5, 15, 53)
apoC-IV	472	0.51	0.26	1.44 × 10−15	8.24 × 10−13	37.8	4502161	(5, 15, 53)
Cathelicidin antimicrobial peptide (CAMP)	394	0.44	0.19	1.18 × 10−6	5.07 × 10−4	25.1	39753970	(53)
Proteoglycan 4 (PRG4)	380	0.40	0.16	7.07 × 10−6	2.43 × 10−3	49.3	189181724
ANTXR2	346	−0.40	0.16	1.85 × 10−5	5.28 × 10−3	−28.3	50513243	(53)
CETP, plasma	465	−0.40	0.16	2.33 × 10−5	5.71 × 10−3	−23.9	169636439	(53)
Neuropilin 1 (NRP1)	432	−0.39	0.15	5.14 × 10−5	1.10 × 10−2	−25.4	66864913
RBP4	472	0.40	0.16	2.45 × 10−4	3.91 × 10−2	30.1	55743122
apoE	472	0.40	0.16	2.45 × 10−4	3.91 × 10−2	30.9	4557325	(53)
PLTP	445	−0.39	0.15	2.73 × 10−4	3.91 × 10−2	−27.9	5453914	(5, 15, 53)
Insulin-like growth factor binding protein 1 (IGFBP1)	417	−0.33	0.11	3.16 × 10−4	4.17 × 10−2	−13.2	4504615

Twelve proteins quantified by MS and estimated by LME modeling in >10% of the samples that were positively and negatively associated with plasma triglycerides adjusting for fasting status (q < 0.05), listed by the strength of association (in increasing order of q).

^aNumber of child plasma samples in which each protein was detected and quantified by MS. Children with triglyceride concentrations below a detection limit (<45 mg/dl) were excluded (n = 28).

^bPercent change in plasma triglycerides of children per 100% (two times) increase in relative abundance of a protein.

^cGenInfo sequence number as assigned to all protein sequences by the NCBI at the National Library of Medicine, National Institutes of Health.

^dProteins have been previously reported to be physically associated with VLDL particles.