TABLE 4.
Proteins positively correlated with plasma HDL-C concentrations in children of rural Nepal aged 6–8 years (n = 464)
| Protein Name | na | r | R2 | P | q | Percent Changeb | Accessionc | Referenced |
| apoA-I | 464 | 0.79 | 0.62 | 7.68 × 10−95 | 1.06 × 10−91 | 183.8 | 4557321 | (7, 10–12, 60, 80–91) |
| IFRD2 | 450 | 0.64 | 0.41 | 3.59 × 10−33 | 2.47 × 10−30 | 63.9 | 197333755 | |
| apoA-II | 464 | 0.58 | 0.34 | 9.04 × 10−24 | 4.16 × 10−21 | 76.9 | 4502149 | (7, 10–12, 60, 80–85, 87–91) |
| apoD | 464 | 0.56 | 0.31 | 8.22 × 10−19 | 2.72 × 10−16 | 53.2 | 4502163 | (7, 12, 60, 80–85, 87–91) |
| EIF2D | 238 | 0.57 | 0.33 | 9.85 × 10−19 | 2.72 × 10−16 | 61.0 | 56699485 | |
| apoC-I | 464 | 0.51 | 0.26 | 1.44 × 10−13 | 2.83 × 10−11 | 18.6 | 4502157 | (7, 10, 11, 60, 80–85, 87–91) |
| apoM | 464 | 0.51 | 0.26 | 7.09 × 10−13 | 1.22 × 10−10 | 54.8 | 22091452 | (7, 10–12, 60, 80–82, 84, 85, 87–91) |
| PLTP | 438 | 0.51 | 0.26 | 1.40 × 10−10 | 2.15 × 10−8 | 50.3 | 5453914 | (7, 60, 80, 81, 87, 88, 91) |
| ANTXR2 | 337 | 0.51 | 0.26 | 1.71 × 10−10 | 2.36 × 10−8 | 42.8 | 50513243 | (60) |
| TMF1 | 228 | 0.54 | 0.29 | 4.74 × 10−9 | 5.95 × 10−7 | 33.0 | 110347443 | |
| KLF17 | 258 | 0.50 | 0.25 | 6.99 × 10−9 | 8.04 × 10−7 | 26.4 | 104294874 | |
| PON1 | 464 | 0.49 | 0.24 | 8.81 × 10−9 | 9.35 × 10−7 | 27.3 | 19923106 | (7, 11, 12, 60, 80–85, 87–91) |
| ANTXR1 | 315 | 0.45 | 0.21 | 2.39 × 10−7 | 2.36 × 10−5 | 30.0 | 14149904 | (60) |
| SAA4 | 459 | 0.47 | 0.22 | 7.79 × 10−7 | 7.17 × 10−5 | 23.9 | 10835095 | (7, 10, 60, 80, 81, 83–85, 87–91) |
| PON3 | 457 | 0.46 | 0.21 | 1.23 × 10−6 | 1.06 × 10−4 | 28.1 | 29788996 | (7, 60, 80, 81, 88, 91) |
| BPI fold containing family B member 1 (BPIFB1) | 189 | 0.52 | 0.27 | 1.91 × 10−6 | 1.55 × 10−4 | 26.6 | 40807482 | (60) |
| apoF | 464 | 0.47 | 0.22 | 3.96 × 10−6 | 3.03 × 10−4 | 24.9 | 4502165 | (7, 60, 80–83, 85, 88–91) |
| Glycosylphosphatidylinositol specific phospholipase D1 (GPLD1) | 464 | 0.46 | 0.21 | 9.82 × 10−6 | 6.73 × 10−4 | 31.6 | 29171717 | (60, 80, 82) |
| Secretoglobin, family 3A member 1 (SCGB3A1) | 279 | 0.54 | 0.29 | 1.02 × 10−5 | 6.73 × 10−4 | 14.7 | 50363226 | (91) |
| LCAT | 464 | 0.45 | 0.20 | 2.94 × 10−5 | 1.69 × 10−3 | 52.3 | 4557892 | (7, 60, 80, 87, 88, 91) |
| apoC-III | 464 | 0.45 | 0.20 | 3.16 × 10−5 | 1.74 × 10−3 | 15.5 | 4557323 | (7, 10–12, 60, 80–91) |
| RBP4 | 464 | 0.45 | 0.21 | 4.47 × 10−5 | 2.37 × 10−3 | 23.4 | 55743122 | (7, 80, 82, 84, 85, 87, 88, 90) |
| CD99 molecule (CD99) | 444 | 0.41 | 0.17 | 4.78 × 10−5 | 2.39 × 10−3 | 17.1 | 171543879 | |
| DNA repair and recombination protein RAD54B (RAD54B) | 98 | 0.54 | 0.29 | 7.95 × 10−5 | 3.66 × 10−3 | 41.2 | 6912622 | |
| apoA-IV | 464 | 0.45 | 0.20 | 9.49 × 10−5 | 4.23 × 10−3 | 18.4 | 71773110 | (7, 10–12, 60, 80–91) |
| Transthyretin (TTR) | 464 | 0.45 | 0.20 | 1.02 × 10−4 | 4.42 × 10−3 | 32.3 | 4507725 | (7, 10–12, 80–82, 84–86, 88, 90, 91) |
| Integrin α2 (ITGA2) | 175 | 0.50 | 0.25 | 1.32 × 10−4 | 5.51 × 10−3 | 31.1 | 116295258 | (60) |
| Exostosin-like glycosyltransferase 2 (EXTL2) | 301 | 0.45 | 0.21 | 2.10 × 10−4 | 7.82 × 10−3 | 21.0 | 14149609 | |
| Golgin B1 (GOLGB1) | 322 | 0.44 | 0.20 | 2.28 × 10−4 | 8.28 × 10−3 | 19.5 | 148596984 | |
| Attractin (ATRN) | 464 | 0.45 | 0.20 | 2.94 × 10−4 | 1.04 × 10−2 | 34.7 | 21450863 | |
| Heat shock 70 kDa protein 12A (HSPA12A) | 107 | 0.47 | 0.22 | 6.29 × 10−4 | 2.01 × 10−2 | 43.2 | 119874213 | |
| Afamin (AFM) | 464 | 0.44 | 0.19 | 7.23 × 10−4 | 2.17 × 10−2 | 21.2 | 4501987 | (80, 82, 87, 90) |
| Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) | 69 | 0.61 | 0.37 | 7.86 × 10−4 | 2.31 × 10−2 | 46.4 | 148886654 | |
| Aldehyde dehydrogenase 9 family member A1 (ALDH9A1) | 85 | 0.53 | 0.28 | 1.11 × 10−3 | 2.99 × 10−2 | 19.9 | 115387104 | |
| Suprabasin (SBSN) | 121 | 0.53 | 0.28 | 1.88 × 10−3 | 4.42 × 10−2 | 39.5 | 38348366 | |
| Plexin domain-containing protein 1 (PLXDC1) | 94 | 0.59 | 0.35 | 2.26 × 10−3 | 4.91 × 10−2 | 29.4 | 5011862 |
Thirty-six proteins quantified by MS and estimated by LME modeling in >10% of the samples that were positively associated with HDL-C adjusting for fasting status (q < 0.05), listed by the strength of association (in increasing order of q).
Number of child plasma samples in which each protein was detected and quantified by MS. Children with plasma HDL-C concentrations below a detection limit (<15 mg/dl) were excluded (n = 36).
Percent change in plasma HDL-C of children per 100% (two times) increase in relative abundance of a protein.
GenInfo sequence number as assigned to all protein sequences by the NCBI at the National Library of Medicine, National Institutes of Health.
Proteins have been previously reported to be physically associated with HDL particles (79).