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. 2018 Nov 25;60(1):149–160. doi: 10.1194/jlr.P088542

TABLE 4.

Proteins positively correlated with plasma HDL-C concentrations in children of rural Nepal aged 6–8 years (n = 464)

Protein Name na r R2 P q Percent Changeb Accessionc Referenced
apoA-I 464 0.79 0.62 7.68 × 10−95 1.06 × 10−91 183.8 4557321 (7, 1012, 60, 8091)
IFRD2 450 0.64 0.41 3.59 × 10−33 2.47 × 10−30 63.9 197333755
apoA-II 464 0.58 0.34 9.04 × 10−24 4.16 × 10−21 76.9 4502149 (7, 1012, 60, 8085, 8791)
apoD 464 0.56 0.31 8.22 × 10−19 2.72 × 10−16 53.2 4502163 (7, 12, 60, 8085, 8791)
EIF2D 238 0.57 0.33 9.85 × 10−19 2.72 × 10−16 61.0 56699485
apoC-I 464 0.51 0.26 1.44 × 10−13 2.83 × 10−11 18.6 4502157 (7, 10, 11, 60, 8085, 8791)
apoM 464 0.51 0.26 7.09 × 10−13 1.22 × 10−10 54.8 22091452 (7, 1012, 60, 8082, 84, 85, 8791)
PLTP 438 0.51 0.26 1.40 × 10−10 2.15 × 10−8 50.3 5453914 (7, 60, 80, 81, 87, 88, 91)
ANTXR2 337 0.51 0.26 1.71 × 10−10 2.36 × 10−8 42.8 50513243 (60)
TMF1 228 0.54 0.29 4.74 × 10−9 5.95 × 10−7 33.0 110347443
KLF17 258 0.50 0.25 6.99 × 10−9 8.04 × 10−7 26.4 104294874
PON1 464 0.49 0.24 8.81 × 10−9 9.35 × 10−7 27.3 19923106 (7, 11, 12, 60, 8085, 8791)
ANTXR1 315 0.45 0.21 2.39 × 10−7 2.36 × 10−5 30.0 14149904 (60)
SAA4 459 0.47 0.22 7.79 × 10−7 7.17 × 10−5 23.9 10835095 (7, 10, 60, 80, 81, 8385, 8791)
PON3 457 0.46 0.21 1.23 × 10−6 1.06 × 10−4 28.1 29788996 (7, 60, 80, 81, 88, 91)
BPI fold containing family B member 1 (BPIFB1) 189 0.52 0.27 1.91 × 10−6 1.55 × 10−4 26.6 40807482 (60)
apoF 464 0.47 0.22 3.96 × 10−6 3.03 × 10−4 24.9 4502165 (7, 60, 8083, 85, 8891)
Glycosylphosphatidylinositol specific phospholipase D1 (GPLD1) 464 0.46 0.21 9.82 × 10−6 6.73 × 10−4 31.6 29171717 (60, 80, 82)
Secretoglobin, family 3A member 1 (SCGB3A1) 279 0.54 0.29 1.02 × 10−5 6.73 × 10−4 14.7 50363226 (91)
LCAT 464 0.45 0.20 2.94 × 10−5 1.69 × 10−3 52.3 4557892 (7, 60, 80, 87, 88, 91)
apoC-III 464 0.45 0.20 3.16 × 10−5 1.74 × 10−3 15.5 4557323 (7, 1012, 60, 8091)
RBP4 464 0.45 0.21 4.47 × 10−5 2.37 × 10−3 23.4 55743122 (7, 80, 82, 84, 85, 87, 88, 90)
CD99 molecule (CD99) 444 0.41 0.17 4.78 × 10−5 2.39 × 10−3 17.1 171543879
DNA repair and recombination protein RAD54B (RAD54B) 98 0.54 0.29 7.95 × 10−5 3.66 × 10−3 41.2 6912622
apoA-IV 464 0.45 0.20 9.49 × 10−5 4.23 × 10−3 18.4 71773110 (7, 1012, 60, 8091)
Transthyretin (TTR) 464 0.45 0.20 1.02 × 10−4 4.42 × 10−3 32.3 4507725 (7, 1012, 8082, 8486, 88, 90, 91)
Integrin α2 (ITGA2) 175 0.50 0.25 1.32 × 10−4 5.51 × 10−3 31.1 116295258 (60)
Exostosin-like glycosyltransferase 2 (EXTL2) 301 0.45 0.21 2.10 × 10−4 7.82 × 10−3 21.0 14149609
Golgin B1 (GOLGB1) 322 0.44 0.20 2.28 × 10−4 8.28 × 10−3 19.5 148596984
Attractin (ATRN) 464 0.45 0.20 2.94 × 10−4 1.04 × 10−2 34.7 21450863
Heat shock 70 kDa protein 12A (HSPA12A) 107 0.47 0.22 6.29 × 10−4 2.01 × 10−2 43.2 119874213
Afamin (AFM) 464 0.44 0.19 7.23 × 10−4 2.17 × 10−2 21.2 4501987 (80, 82, 87, 90)
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1) 69 0.61 0.37 7.86 × 10−4 2.31 × 10−2 46.4 148886654
Aldehyde dehydrogenase 9 family member A1 (ALDH9A1) 85 0.53 0.28 1.11 × 10−3 2.99 × 10−2 19.9 115387104
Suprabasin (SBSN) 121 0.53 0.28 1.88 × 10−3 4.42 × 10−2 39.5 38348366
Plexin domain-containing protein 1 (PLXDC1) 94 0.59 0.35 2.26 × 10−3 4.91 × 10−2 29.4 5011862

Thirty-six proteins quantified by MS and estimated by LME modeling in >10% of the samples that were positively associated with HDL-C adjusting for fasting status (q < 0.05), listed by the strength of association (in increasing order of q).

a

Number of child plasma samples in which each protein was detected and quantified by MS. Children with plasma HDL-C concentrations below a detection limit (<15 mg/dl) were excluded (n = 36).

b

Percent change in plasma HDL-C of children per 100% (two times) increase in relative abundance of a protein.

c

GenInfo sequence number as assigned to all protein sequences by the NCBI at the National Library of Medicine, National Institutes of Health.

d

Proteins have been previously reported to be physically associated with HDL particles (79).