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. 2018 Nov 15;60(1):58–70. doi: 10.1194/jlr.M086843

Fig. 6.

Fig. 6.

LCSFAs palmitate and stearate alter mitochondrial morphology in mouse DRG neurons. Mitochondrial circularity was not significantly affected by 250 μM laurate or 250 μM myristate (A, B), but a significant increase in circularity was observed in 250 μM palmitate and 250 μM stearate-treated DRG neurons (C, D). E, F: The distribution of mitochondrial size in DRG neurons treated with 250 μM laurate and myristate matched the mitochondrial size profile of the 0.25% BSA control. G, H: Treatment with 250 μM palmitate or 250 μM stearate induced a shift in the mitochondrial size profile, resulting in larger mitochondria relative to the 0.25% BSA control. The number of DRG neurons analyzed for changes in mitochondrial morphology are listed in the box plot of each condition. Values are expressed as mean ± SEM. * P < 0.05, unpaired t-test for mitochondrial circularity and Kolmogorov-Smirnov test for mitochondrial size distribution.