Fig. 7.

Caspase 3/7 activity is increased in 50B11 DRG neurons exposed to elevated levels of palmitate and stearate. No significant increases in caspase 3/7 activity resulted from laurate and myristate treatments ranging from 62.5 to 250 μM compared with the TM and 0.25% BSA control. Concentrations of 187.5–250 μM palmitate and stearate led to a dose-dependent amplification of caspase 3/7 activity, whereas 62.5 μM palmitate and stearate maintained basal caspase 3/7 activation levels. Values are expressed as mean ± SEM. * P < 0.01, ordinary one-way ANOVA with Tukey’s multiple-comparisons test.