TABLE 2.

PCSK9, major lipids, and noncholesterol sterols according to pretreatment

	No Pretreatment	Ezetimibe	Statin	Ezetimibe + Statin	a
Number	84	26	38	97
PCSK9, ng/mlb	279 (22)	296 (43)	327 (36)	442 (23)	<0.001
Total cholesterol, mmol/l	7.27 (0.19)	6.62 (0.39)	6.18 (0.23)	5.46 (0.15)	<0.001
LDL-cholesterol, mmol/l	4.57 (0.17)	4.17 (0.38)	3.88 (0.19)	3.37 (0.12)	<0.001
HDL-cholesterol, mmol/l	1.17 (0.04)	1.21 (0.07)	1.34 (0.07)	1.16 (0.04)	0.101
Total triglycerides, mmol/l	2.45 (0.18)	2.02 (0.21)	1.67 (0.20)	1.69 (0.11)	<0.001
Lathosterol, μmol/l	18.9 (1.2)	24.8 (3.2)	6.3 (0.8)	7.4 (1.0)	<0.001
Campesterol, μmol/l	16.3 (1.2)	6.8 (0.8)	19.2 (1.6)	11.6 (1.1)	<0.001
Sitosterol, μmol/l	17.2 (1.0)	10.4 (1.3)	21.5 (1.7)	15.9 (1.2)	<0.001
Lathosterol:cholesterol, μmol/mmol	2.6 (0.2)	3.8 (0.4)	1.0 (0.1)	1.3 (0.2)	<0.001
Campesterol:cholesterol, μmol/mmol	2.2 (0.1)	1.1 (0.1)	3.1 (0.2)	2.2 (0.2)	<0.001
Sitosterol:cholesterol, μmol/mmol	2.4 (0.1)	1.6 (0.2)	3.6 (0.3)	3.0 (0.2)	<0.001
Campesterol:lathosterol	1.3 (0.2)	0.6 (0.2)	5.4 (1.0)	2.5 (0.3)	<0.001
Sitosterol:lathosterol	1.4 (0.2)	0.9 (0.3)	5.9 (0.9)	3.8 (0.5)	<0.001

Values are means with standard error.

^aCalculated with ANOVA.

^bNumbers: 14/4/10/19.