TABLE 3.

Effects of PCSK9-antibodies on PCSK9, major lipids, and noncholesterol sterols

Lipids	Absolute Change	Percent Change	a
PCSK9, ng/mlb	2,459 (115)	760 (45)	<0.001
Total cholesterol, mmol/l	−2.44 (0.08)	−38.8 (0.9)	<0.001
LDL-cholesterol, mmol/l	−2.02 (0.06)	−52.1 (1.7)	<0.001
HDL-cholesterol, mmol/l	0.14 (0.01)	13.8 (1.5)	<0.001
Total triglycerides, mmol/l	−0.48 (0.05)	−17.1 (1.8)	<0.001
Lathosterol, μmol/l	−5.57 (0.55)	−30.4 (3.5)	<0.001
Campesterol μmol/l	−4.78 (0.54)	−30.8 (3.1)	<0.001
Sitosterol, μmol/l	−5.22 (0.59)	−26.5 (3.0)	<0.001
Lathosterol:cholesterol, μmol/mmol	−0.14 (0.08)	12.7 (5.0)	0.744
Campesterol:cholesterol, μmol/mmol	0.08 (0.11)	12.6 (4.8)	0.819
Sitosterol:cholesterol, μmol/mmol	0.28 (0.13)	20.1 (4.4)	0.009
Campesterol:lathosterol	−0.16 (0.11)	18.2 (7.0)	0.597
Sitosterol:lathosterol	0.09 (0.15)	27.8 (7.9)	0.010

Values are means with standard error.

^aCalculated with paired samples t-test.

^bNumber: 46.