TABLE 4.
Changes of PCSK9, major lipids, and noncholesterol sterols in response to PCSK9-antibodies according to pretreatment
| No Pretreatment | Ezetimibe | Statin | Ezetimibe + Statin | a | |
| Number | 84 | 26 | 38 | 97 | |
| PCSK9b | 0.263 | ||||
| Absolute, ng/ml | 2120 (163) | 2592 (354) | 2315 (145) | 2772 (224) | |
| Percent | 814 (80) | 971 (236) | 770 (78) | 667 (69) | |
| Total cholesterol | 0.265 | ||||
| Absolute, mmol/l | −2.73 (0.13) | −2.44 (0.17) | −2.24 (0.22) | −2.27 (0.12) | |
| Percent | −37.4 (1.4) | −37.5 (2.1) | −36.8 (3.4) | −41.1 (1.5) | |
| LDL-cholesterol | 0.305 | ||||
| Absolute, mmol/l | −2.18 (0.10) | −2.07 (0.15) | −1.90 (0.21) | −1.90 (0.09) | |
| Percent | −48.6 (1.9) | −51.9 (3.0) | −50.5 (5.4) | −55.9 (3.2) | |
| HDL-cholesterol | 0.118 | ||||
| Absolute, mmol/l | 0.14 (0.02) | 0.22 (0.06) | 0.13 (0.04) | 0.11 (0.02) | |
| Percent | 14.0 (1.9) | 23.8 (8.7) | 10.4 (2.7) | 12.1 (2.3) | |
| Total triglycerides | 0.990 | ||||
| Absolute, mmol/l | −0.63 (0.11) | −0.47 (0.18) | −0.41 (0.14) | −0.37 (0.07) | |
| Percent | −18.0 (3.0) | −16.3 (6.4) | −16.6 (4.9) | −16.9 (2.8) | |
| Lathosterol | 0.428 | ||||
| Absolute, μmol/l | −7.96 (0.91) | −9.96 (1.88) | −2.00 (0.71) | −3.72 (0.91) | |
| Percent | −26.5 (8.4) | −31.2 (6.2) | −21.8 (8.7) | −37.0 (3.3) | |
| Campesterol | 0.655 | ||||
| Absolute, μmol/l | −4.42 (1.04) | −2.30 (0.63) | −6.40 (1.19) | −5.12 (0.91) | |
| Percent | −26.3 (5.2) | −30.8 (7.0) | −28.8 (7.9) | −35.4 (5.5) | |
| Sitosterol | 0.158 | ||||
| Absolute, μmol/l | −3.79 (1.00) | −3.45 (1.13) | −6.64 (1.68) | −6.39 (0.94) | |
| Percent | −21.7 (5.1) | −18.3 (12.2) | −21.5 (9.2) | −34.8 (3.6) | |
| Lathosterol:cholesterol | 0.912 | ||||
| Absolute, μmol/mmol | −0.15 (0.11) | −0.24 (0.23) | 0.05 (0.12) | −0.17 (0.15) | |
| Percent | 13.9 (11.5) | 8.6 (7.8) | 20.0 (9.2) | 9.9 (6.8) | |
| Campesterol:cholesterol | 0.946 | ||||
| Absolute, μmol/mmol | 0.30 (0.19) | 0.02 (0.09) | 0.21 (0.25) | −0.15 (0.19) | |
| Percent | 16.4 (7.4) | 8.0 (8.4) | 10.0 (8.6) | 11.5 (9.6) | |
| Sitosterol:cholesterol | 0.658 | ||||
| Absolute, μmol/mmol | 0.58 (0.25) | 0.09 (0.16) | 0.42 (0.36) | 0.01 (0.20) | |
| Percent | 24.7 (7.9) | 27.8 (16.5) | 21.8 (11.6) | 13.4 (6.3) | |
| Campesterol:lathosterol | 0.719 | ||||
| Absolute | −0.01 (0.18) | −0.09 (0.07) | −0.95 (0.54) | 0.01 (0.18) | |
| Percent | 24.5 (8.3) | 5.4 (8.0) | 29.2 (36.3) | 11.8 (7.6) | |
| Sitosterol:lathosterol | 0.562 | ||||
| Absolute | 0.22 (0.33) | −0.12 (0.11) | −0.25 (0.43) | 0.17 (0.18) | |
| Percent | 37.2 (10.7) | 23.7 (14.0) | 42.5 (41.7) | 15.1 (6.0) |
Values are means with standard error.
a
Calculated with ANOVA of percent changes.
b
Numbers: 14/4/10/19.