TABLE 5.

Multivariable regression analysis demonstrating the positive association of serum paraoxonase-1 activity with an elevated FLI (≥60) after adjusting for clinical and laboratory covariates in 5,126 subjects, excluding subjects with a positive cardiovascular history, impaired estimated glomerular filtration rate, and elevated UAE and those using antihypertensive, glucose-lowering, and lipid-lowering drugs

	Model 1a		Model 2b		Model 3c
	β	P	β	P	β	P
Age	−0.062	<0.001	−0064	<0.001	−0.085	<0.001
Sex (men vs. women)	−0.078	<0.001	−0.093	<0.001	−0.106	<0.001
FLI ≥60 vs. <60	0.031	0.030	0.050	0.003	0.045	0.017
T2D (yes/no)			−0.012	0.38
MetS (yes/no)			−0.032	0.057
Alcoholic intake ≥10 g/day			0.074	<0.001	0.051	<0.001
Current smoking (yes/no)			−0.067	<0.001	−0.046	0.001
Elevated blood pressure					0.037	0.013
Enlarged waist					−0.020	0.23
Elevated glucose					−0.001	0.97
Low HDL cholesterol					−0.185	<0.001
Elevated triglycerides					0.076	<0.001

^aAdjusted for age and sex.

^bAdjusted for age, sex, T2D, MetS, alcohol consumption, and current smoking.

^cAdjusted for age, sex, waist circumference, and individual MetS criteria (elevated blood pressure, enlarged waist, elevated glucose, low HDL cholesterol).