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Bile acid profiles in different compartments of the DKO and their Mdr2−/− controls, Bsep−/−, and their controls (n = 4 per genotype), measured using UPLC/MRM-MS. A: Total bile acids in the plasma, liver, bile, and feces of female mice at 8 weeks of age. B: The percentage distribution of major bile acids. Asterisks indicate the statistical significance between genotypes obtained by one-way ANOVA tests. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001. ns, not significant.
