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Molecular Alterations Present in Tumor of Patients with LM. a. Suspected EGFR activating mutations defined as a patient who had a documented response to gefitinib or erlotinib on imaging in the absence of EGFR mutation testing.
| Molecular Alteration | Percent (number/total) |
|---|---|
| - K-ras mutation | 7% (2/30) |
| - Known or Suspected EGFR activating mutationa | 43% (13/30) |
| - ALK translocation | 7% (2/30) |
| - EGFR Exon 20 insertion/PI3K mutation | 3% (1/30) |
| - None/Unknown | 40% (12/30) |
