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. 2019 Jan 7;151(1):9–17. doi: 10.1085/jgp.201812131

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© 2018 Tikunova et al.

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Figure 3. — Titrations of 3-Cl-DPA, TFP, and bepridil into Ca²⁺-saturated intact cTnC. (A–C) Titrations of 3-Cl-DPA (A), TFP (B), or bepridil (C) into ¹⁵N-labeled cTnC, observed by 2D [¹H,¹⁵N]-HSQC NMR spectra (amide HN ¹H chemical shift plotted along x axis, amide ¹⁵N chemical shift plotted along y axis). For each titration, all spectra have been overlaid, with peaks plotted as a single contour level so that their progression can be tracked (shown by arrows). The final spectrum at the end of the titration is plotted conventionally with multiple contour levels. For 3-Cl-DPA, note many peaks disappear and do not reappear at the end of the titration.