Figure 3.

Percentage of participants who achieved a 4-fold or greater increase in anti-measles, anti-mumps, or anti-rubella virus antibody concentrations at Day 42 (ATP cohort for immunogenicity). Footnote: N, number of participants with both pre- and post-vaccination available results; ATP, according-to-protocol.

For participants with a seronegative status at pre-vaccination, a 4-fold rise in antibody concentration is defined as 4 times the cut-off level of the assay. Cut-off levels for anti-measles, anti-mumps and anti-rubella virus antibody concentrations are 150 mIU/mL, 5 EU/mL and 4 IU/mL, respectively. The error bars represent the upper and lower limits of the two-sided 95% confidence intervals obtained using the Clopper Pearson method.