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. Author manuscript; available in PMC: 2019 Jan 2.
Published in final edited form as: Nat Rev Drug Discov. 2016 Dec 2;16(1):19–34. doi: 10.1038/nrd.2016.230

Figure 4.

Figure 4

Promiscuity of privileged protein family classes. Each node in the outer ring corresponds to a drug represented by its ATC code(s). The outer ring corresponds to the level 1 of the ATC code (see Table 2) scaled to the number of drugs in that category. The inner ring represents the level 2 of the ATC code. A node is connected to another when two drugs have an efficacy target that belongs to the same target class. (a) Footprint of privileged family classes modulated by organic small-molecule drugs across disease. (b) Footprint of privileged family classes modulated by biologic drugs across disease. G-protein coupled receptor 1 family (blue); Voltage-gated ion channel (orange); Ligand-gated ion channel (green); Kinase (black). Drugs without an ATC code (U – Unclassified) were excluded from this analysis.