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. Author manuscript; available in PMC: 2019 Jan 2.
Published in final edited form as: Nat Rev Drug Discov. 2016 Dec 2;16(1):19–34. doi: 10.1038/nrd.2016.230

Table 3.

Drug efficacy targets unique to non FDA approved drugs

Tipiracil is an adjuvant used in the treatment of colorectal cancer to potentiate the action of trifluridine. ATC; WHO Anatomical Therapeutic Chemical Classification System, NA; not applicable

Target Name UniProt Accession Number Example drug ATC class Indication
Aldose reductase P15121 Tolrestat A10XA Diabetic complications
Melanocyte-stimulating hormone receptor Q01726 Afamelanotide D02BB Erythropoietic Protoporphyria
P2Y purinoceptor 2 P41231 Diquafosol NA Dry eye
Rho-associated protein kinase 1 Q13464 Ripasudil NA Glaucoma
Rho-associated protein kinase 2 O75116 Ripasudil NA Glaucoma
Transthyretin P02766 Tafamidis N07XX Amyloidosis
Troponin C, slow skeletal and cardiac muscles P63316 Levosimendan C01CX Congestive heart failure
Thymidine phosphorylase P19971 Tipiracil NA Colorectal cancer