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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2018 Nov 14;1866(2):252–263. doi: 10.1016/j.bbamcr.2018.11.005

Table 1. Amino acid sequence alignment of C-termini of selected SLC6 transporters.

Transporter Amino acid sequence of C-terminus
rATB0,+ KIVRAEG-NILQRIIKCCRPASNWGPYLEKHRGERYKDMA----EPAK---------------------ETDHEIPT-ISGTRKPE
hSERT RLIITPG-TFKERIIKSITPETPTEIP-C-------------------------------------------GD------IRLNAV
hGAT1 MFLTLKG-SLKQRIQVMVQPSEDIV-RPE-NGPE----------------------------------QP-Q--AGS-STSKEAYI

The ER export motifs RI are indicated in bold, the residues proposed [19] determine binding of SEC24C (lysine) and SEC24D (valine) are indicated in bold underlined type. Multiple sequence alignment was performed with use of T-coffee programme [32]. The accession numbers for rat ATB0,+ - NM_001037544, for human SERT - NP_001036 and for human GAT1 - NP_003033.